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Esmaeili N, Gell L, Imler T, et al

Clinical data from SURMOUNT trials demonstrated that this dual-receptor approach produces weight loss significantly greater than GLP-1-only medications achieve at comparable doses

J Biol Chem 277:43536 Hashimoto W, Suzuki H, Nohara S, Tachi H, Yamamoto K, Kumagai H (1995) Subunit association of gamma-glutamyltranspeptidase of Escherichia coli K-12

6-BPPI was an effective antagonist of the GLP-1R but was inactive on a chimeric receptor composed of the ectodomain of the gastric inhibitory polypeptide receptor (GIPR) fused to the 7TM domains of the GLP-1R

Donates electrons via its reduced thiol (GSH) to neutralize reactive oxygen species directly or through glutathione peroxidase